C101

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C101

Sigma

 

8-Cyclopentyl-1,3-dipropylxanthine

solid

Synonym:1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948
CAS Number:102146-07-6
Linear Formula:C16H24N4O2
Molecular Weight:304.39
MDL number:MFCD00055117
PubChem Substance ID:24277697

Details

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Description

Biochem/physiol ActionsSelective A1 adenosine receptor antagonist.

Properties

formsolid
color white
solubilityDMSO: >10 mg/mL
 0.1 M NaOH: 2 mg/mL
 ethanol: 4 mg/mL
 H2O:  insoluble
abs.εmax/276 nm, ethanol 14,800
Gene Informationhuman ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
 rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany3

References

referenceHaleen, et al., PD 116,948, a highly selective A1 adenosine receptor antagonist. Life Sci. 40, 555-561, (1987) Abstract
 Bruns, et al., Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn Schmiedebergs Arch. Pharmacol. 335, 59-63, (1987) Abstract
 Lee, et al., 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N-ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors. Brain Res. 368, 394-398, (1986) Abstract